MyBioSource Introduces Validated anti-CALB2 Antibody for Neuroscience Research

MyBioSource, a leader in delivering highly validated life science reagents, has added Sheep anti-Rat Calretinin Polyclonal antibody to its catalog for advanced research applications. The antibody, designated MBS502148, is designed for researchers studying calretinin (CALB2), a vital calcium-binding protein with widespread significance in neurobiology and cellular calcium signaling. Calretinin, with a molecular weight of 29kDa, is predominantly expressed in nerve cells throughout the central nervous system, retina, and other tissues, playing essential roles in buffering intracellular calcium, maintaining cellular homeostasis, and contributing to neuroprotection.

The anti-CALB2 antibody supplied by MyBioSource recognizes the rat calretinin protein and, due to 100% sequence homology, offers potential cross-reactivity with mouse, human, and non-human primate calretinin. Key features include its host and clonality as sheep polyclonal antibodies, specificity targeting calretinin protein at approximately 29kDa confirmed by Western blot of rat brain lysate, and immunogen derived from purified guinea pig calretinin protein. Researchers can access detailed information about this product through the official MyBioSource website.

This antibody is validated for multiple techniques including Western Blot (WB), Immunohistochemistry (IHC) on formalin or paraformaldehyde perfused rat brain tissues, and Immunofluorescence (IF). It undergoes Protein A purification for high specificity and low background noise, ensuring reliable performance in experimental settings. The antibody is stable at -20°C, though researchers are advised to avoid repeated freeze/thaw cycles to maintain integrity. It is specifically designed for neuroscience research involving neurodegeneration, calcium signaling, cellular mechanisms of calcium buffering, and auditory neuron studies.

The cross-species reactivity makes this antibody particularly valuable for comparative studies across mouse, human, and non-human primate models, enhancing its utility in diverse research contexts. Calretinin's importance in neuroprotective roles and its function as a marker in neurological studies—such as analyzing calcium dynamics and neuronal resistance to excitotoxicity—underscore the antibody's relevance. It is integral for academicians and researchers focused on elucidating mechanisms of calcium regulation, neuronal function, and related biological pathways, while also supporting studies in neurodegeneration, auditory neuroscience, and developmental biology. The anti-CALB2 antibody is intended for research use only and is not suitable for diagnostic, therapeutic, or clinical applications.