National Survey Reveals Nearly Half of Americans Experience Unexplained Pain and Illness
October 1st, 2025 7:00 AM
By: Newsworthy Staff
A new national survey shows 48% of Americans suffer from chronic unexplained pain or illness, highlighting the urgent need for greater awareness and access to neuroplastic treatment approaches that could transform healthcare outcomes.

A new national survey of more than 1,500 U.S. adults has found that nearly half of Americans (48%) are living with ongoing pain or illness that either has no clear explanation or is not responding to medical treatment as expected. The survey, conducted by the Association for the Treatment of Neuroplastic Symptoms in partnership with XandY, reveals the staggering prevalence of different types of unexplained symptoms and how the public understands their potential causes and treatments. Tens of millions of Americans suffer from chronic pain or illness that is not always caused by injury or disease, representing a massive healthcare burden that costs more than diabetes, cancer, and heart disease combined.
The research shows that the brain can generate pain or illness anywhere in the body through learned nerve pathways that are reversible, known as neuroplastic symptoms. Stress, trauma, emotions, and other life challenges are key contributors to these conditions. According to David Clarke, MD, President of ATNS and a board-certified gastroenterologist, "There are highly effective treatments for these conditions, but few people know about them. They work by training your brain to recognize and turn off unnecessary danger signals. What is most needed now is greater awareness, widespread professional training, and much better access to these solutions."
The survey findings demonstrate that these conditions are far from rare and represent some of the most common reasons people seek medical care. Among those most likely to have neuroplastic symptoms, 63% have been experiencing their current symptoms for up to five years, while 37% have had their symptoms for more than five years. The diversity of symptoms is extensive, with 65% reporting chronic back or neck pain; 57% experiencing muscle, limb, or joint pain; 43% suffering from chronic fatigue; and 35% dealing with headaches or migraines. Most individuals live with several conditions simultaneously, compounding their suffering and healthcare challenges.
Significantly, the survey reveals substantial public openness to psychological approaches for these conditions. Of people with symptoms, 76-97% believe their symptom could have a psychological cause at least "some of the time." Among those most likely to have neuroplastic symptoms, 47% say they are either "definitely" or "probably" willing to try neuroplastic psychological treatment, while only 20% say they "definitely" or "probably" would not. This acceptance level suggests a promising foundation for implementing effective treatment approaches if barriers to access can be addressed.
Clinical evidence strongly supports the effectiveness of neuroplastic recovery therapies. Recent trials have documented far better outcomes compared to older methods. In the Boulder Back Pain study available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848395/, pain improved by an average of 75% in just four weeks. At UCLA, male veterans achieved at least 30% pain relief nearly four times as often (63%) as those treated with traditional cognitive-behavioral therapy (17%). Co-author Matthew Goldberg, PhD emphasized, "This is not a fringe issue. Chronic, unexplained pain and illness are an urgent problem for many. Awareness of and access to effective treatments can be life-changing, as it has been for me."
The survey results offer tremendous hope that people suffering from neuroplastic conditions would accept and benefit from effective treatment if they become aware of it and if barriers to access are addressed. Co-author Abel Gustafson, PhD stated, "These findings are a roadmap for change. Our long-term vision is to dramatically increase the understanding and treatment of neuroplastic symptoms among the public, patients, and practitioners. They must be better equipped to recognize neuroplastic symptoms and see that healing is possible." The organization has released educational resources including a short video illustrating the human stories behind the research and providing information through their website at https://www.symptomatic.me.
Source Statement
This news article relied primarily on a press release disributed by 24-7 Press Release. You can read the source press release here,
